Perturbed Zinc Homeostasis in Rural 3-5-y-Old Malawian Children Is Associated With Abnormalities in Intestinal Permeability Attributed to Tropical Enteropathy.
MANARY, MICAH J.; ABRAMS, STEVEN A.; GRIFFIN, IAN J.; QUIMPER, MEGAN M.; SHULMAN, ROBERT J.; HAMZO, MARIA G.; CHEN, ZHENSHENG; MALETA, KENNETH; MANARY, MARK J.
[Article] Pediatric Research. 67(6):671-675, June 2010.

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Tropical enteropathy and zinc deficiency are major public health problems worldwide. Tropical enteropathy is characterized by reduced mannitol absorption with normal or increased lactulose absorption when a dual sugar absorption test is administered, the results of which are reported as the lactulose:mannitol ratio (L:M). Zinc homeostasis is quantified with a dual stable isotope test. This study tested the hypothesis that endogenous fecal zinc (EFZ) was correlated with the L:M. A dual sugar absorption test and dual stable isotope test were performed on 25 asymptomatic Malawian children aged 3-5 y at risk for tropical enteropathy and zinc deficiency. EFZ and net zinc retention were estimated and correlated with the L:M. Twenty-two children (88%) had an abnormal L:M (L:M >0.10), and the L:M was 0.24 /- 0.10 (mean /- SD). EFZ was 1.68 /- 1.06 mg/d, a quantity greater than is seen in healthy populations from the developed world. EFZ was positively correlated with the L:M (r = 0.62, p < 0.001). Net zinc retention (0.67 /- 1.6 mg/d) was negatively correlated with the L:M (r = -0.47, p = 0.02). This suggests that perturbed zinc homeostasis is associated with subclinical enteropathy in these children.

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