Regulation of cap-dependent translation by eIF4E inhibitory proteins.
Richter, Joel D. 1; Sonenberg, Nahum 2
[Miscellaneous Article]
Nature.
433(7025):477-480, February 3, 2005.
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Eukaryotic messenger RNAs contain a modified guanosine, termed a cap, at their 5' ends. Translation of mRNAs requires the binding of an initiation factor, eIF4E, to the cap structure. Here, we describe a family of proteins that through a shared sequence regulate cap-dependent translation. The biological importance of this translational regulation is immense, and affects such processes as cell growth, development, oncogenic transformation and perhaps even axon pathfinding and memory consolidation.
(C) 2005 Nature Publishing Group