The complete genome sequence of the gastric pathogen Helicobacter pylori.
Tomb, Jean-F.; White, Owen; Kerlavage, Anthony R.; Clayton, Rebecca A.; Sutton, Granger G.; Fleischmann, Robert D.; Ketchum, Karen A.; Klenk, Hans Peter; Gill, Steven; Dougherty, Brian A.; Nelson, Karen; Quackenbush, John; Zhou, Lixin; Kirkness, Ewen F.; Peterson, Scott; Loftus, Brendan; Richardson, Delwood; Dodson, Robert; Khalak, Hanif G.; Glodek, Anna; McKenney, Keith; Fitzegerald, Lisa M.; Lee, Norman; Adams, Mark D.; Hickey, Erin K.; Berg, Douglas E.; Gocayne, Jeanine D.; Utterback, Teresa R.; Peterson, Jeremy D.; Kelley, Jenny M.; Cotton, Matthew D.; Weidman, Janice M.; Fujii, Claire; Bowman, Cheryl; Watthey, Larry; Wallin, Erik; Hayes, William S.; Borodovsky, Mark; Karp, Peter D.; Smith, Hamilton O.; Fraser, Claire M.; Venter, J. Craig
[Article]
Nature.
388(6642):539-547, August 7, 1997.
(Format: HTML)
Helicobacter pylori, strain 26695, has a circular genome of 1,667,867 base pairs and 1,590 predicted coding sequences.Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification. Many putative adhesins, lipoproteins and other outer membrane proteins were identified, underscoring the potential complexity of host-pathogen interaction. Based on the large number of sequence-related genes encoding outer membrane proteins and the presence of homopolymeric tracts and dinucleotide repeats in coding sequences, H. pylori, like several other mucosal pathogens, probably uses recombination and slipped-strand mispairing within repeats as mechanisms for antigenic variation and adaptive evolution. Consistent with its restricted niche, H. pylori has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity. Its survival in acid conditions depends, in part, on its ability to establish a positive inside-membrane potential in low pH.
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