Structure of the complex between human T-cell receptor, viral peptide and HLA-A2.
Garboci, David N.; Ghosh, Partho; Utz, Ursula; Fan, Qing R.; Biddison, William E.; Wiley, Don C.
[Article]
Nature.
384(6605):134-141, November 14, 1996.
(Format: HTML)
Recognition by a T-cell antigen receptor (TCR) of peptide complexed with a major histocompatibility complex (MHC) molecule occurs through variable loops in the TCR structure which bury almost all the available peptide and a much larger area of the MHC molecule. The TCR fits diagonally across the MHC peptide-binding site in a surface feature common to all class I and class II MHC molecules, providing evidence that the nature of binding is general. A broadly applicable binding mode has implications for the mechanism of repertoire selection and the magnitude of alloreactions.
(C) 1996 Macmillan Magazines Ltd.