Identification of a major co-receptor for primary isolates of HIV-1.
Deng, HongKui; Liu, Rong; Ellmeier, Wilfried; Choe, Sunny; Unutmaz, Derya; Burkhart, Michael; Di Marzio, Paola; Marmon, Shoshana; Sutton, Richard E.; Hill, C. Mark; Davis, Craig B.; Peiper, Stephen C.; Schall, Thomas J.; Littman, Dan R.; Landau, Nathaniel R.
[Article]
Nature.
381(6584):661-666, June 20, 1996.
(Format: HTML)
Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry of macrophage-tropic viruses, which are believed to be the key pathogenic strains in vivo. The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the beta-chemokines RANTES, MIP-1 alpha and MIP-1 beta.
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