Information de reference pour ce titreAccession Number: | 00005084-200507530-00002.
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Author: | Packer, Roger J.
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Institution: | Center for Neuroscience and Behavioral Medicine, USA; Department of Neurology, Children's National Medical Center, 111 Michigan Avenue, Washington, DC, USA; Department of Neurology, The George Washington University, USA; University of Virginia, Charlottesville, VA, USA
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Title: | Progress and challenges in childhood brain tumors.[Article]
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Source: | Journal of Neuro-Oncology. 75(3):239-242, 2005.
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Abstract: | Summary: Although many challenges lie ahead, there has been definite progress made in the management of childhood brain tumors. Some of these advances have increased progression-free and overall survival. Other advances, while not improving survival, have resulted in a better quality of life for long-term survivors. Probably the best example of progress is manifest in the outcome of children with medulloblastoma. Seventy percent, and in some subsets as high as 80% of children with this disease can be expected to be cured, compared to approximately 50% three decades ago. This improvement in disease control has been associated with a reduction in the dose of radiotherapy for many patients and possibly an improved quality of survival. For other tumor types, especially brain stem gliomas, there has been little progress made. A primary challenge in the years ahead will be how to integrate biologic discoveries into the care of children for brain tumors, with the hope that molecular biologically based therapy will be more effective and improve the quality of life for survivors.
(C)2005 Kluwer Academic Publishers
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Author Keywords: | brain stem gliomas; chemotherapy; childhood brain tumors; medulloblastoma; radiation therapy; stem gliomas.
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References: | 1. Statistical Report: Primary Brain Tumors in the United States, 1995-1999. Published by the Central Brain Tumor Registry of the United States. CBTRUS, 2002
2. Evans AE, Jenkin RD, Sposto R: The treatment of medulloblastoma: results of a prospective randomized trial of radiation therapy with and without CCNU, vincristine, and prednisone. J Neurosurg 72: 572-582, 1990
3. Tait DM, Thorton-Jones M, Bloom MJA: Adjuvant chemotherapy for medulloblastoma: the first multicenter controlled trial of the International Society of Pediatric Oncology (SIOPI). Eur J Cancer 26: 464-469, 1990
4. Packer RJ, Sutton LN, Elterman R: Outcome for children with medulloblastoma treated with radiation and cisplatin, CCNU, and vincristine chemotherapy. J Neurosurg 81: 690-698, 1994
5. Packer RJ, Goldwein J, Nicholson HS: Treatment of children with medulloblastomas with reduced-dose craniospinal radiation therapy and adjuvant chemotherapy: a Children's Cancer Group study. J Clin Oncol 17: 2127-2136, 1999
6. Zeltzer PM, Boyett JM, Finlay JL: Metastasis stage, adjuvant treatment and residual treatment are prognostic factors for medulloblastoma in children: conclusions from the Children's Cancer Group 921 randomized phase III study. J Clin Oncol 17: 832-845, 1999
7. Pollack IF, Polinko P, Albright AL: Mutism and pseudobulbar symptoms after resection of posterior fossa tumors in children: incidence and pathophysiology. Neurosurgery 37: 885-893, 1995
8. Pomeroy SL, Tamayo P, Gaasenbeck M: Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature 415: 436-442, 2002
9. Rorke LB, Packer RJ, Biegel JA: Central nervous system atypical teratoid/rhabdoid tumors of infancy and childhood: definition of an entity. J Neurosurg 85: 56-65, 1996
10. Duffner PK, Horowitz MD, Krischer JP: Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors. N Engl J Med 328: 1725-1731, 1993
11. Horn B, Heideman R, Geyer R: A multi-institutional retrospective study of intracranial ependymoma in children: identification of risk factors. J Pediatr Hematol Oncol 21: 203-211, 1999
12. Robertson PL, Zeltzer PM, Boyett JM: Survival and prognostic factors following radiation and chemotherapy for ependymomas in children: a report of the Children's Cancer Group. J Neurosurg 88: 685-694, 1998
13. Merchant TE, Mulhern RK, Krasin MJ: Preliminary results from a phase II trial of conformal radiation therapy and evaluation of radiation-related CNS effects for pediatric patients with localized ependymoma. J Clin Oncol 22: 3156-3162, 2004
14. Grill J, LeDelay MC, Gambarell E: Post-operative chemotherapy without irradiation for ependymoma in children under 5 years of age: a multi-centered trial of the French Society of Pediatric Oncology. J Clin Oncol 19: 1288-1296, 2001
15. Packer RJ, Ater J, Allen J: Carboplatin and vincristine chemotherapy for children with newly diagnosed progressive low-grade gliomas. J Neurosurg 86: 747-754, 1997
16. Packer RJ, Allen JC, Goldwein JL: Hyperfractionated radiotherapy for children with brainstem gliomas: a pilot study using 7,200 cGy. Ann Neurol 27: 167-173, 1990
17. Packer RJ, Vezina LG: Management of brain stem gliomas. In: Tindall GT (ed) Gliomas. Neurosurgical Consultations, Vol. 4: pp. 1-7, 1993
18. Finlay J, Boyett J, Yates A: Randomized phase II trial in childhood high-grade astrocytoma comparing vincristine, lomustine and prednisone with eight-drug-in-1-day regimen. J Clin Oncol 3: 112-123, 1995
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Language: | English.
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Document Type: | Special Issue: Childhood Brain Tumors.
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Journal Subset: | Clinical Medicine.
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ISSN: | 0167-594X
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NLM Journal Code: | jcp, 8309335
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