Information de reference pour ce titreAccession Number: | 00004686-200905000-00034.
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Author: | Stanhope, Kimber L. 1,2; Schwarz, Jean Marc 3,4; Keim, Nancy L. 5; Griffen, Steven C. 6; Bremer, Andrew A. 7; Graham, James L. 1,2; Hatcher, Bonnie 2; Cox, Chad L. 2; Dyachenko, Artem 3; Zhang, Wei 6; McGahan, John P. 8; Seibert, Anthony 8; Krauss, Ronald M. 9; Chiu, Sally 9; Schaefer, Ernst J. 10; Ai, Masumi 10; Otokozawa, Seiko 10; Nakajima, Katsuyuki 10,11; Nakano, Takamitsu 11; Beysen, Carine 12; Hellerstein, Marc K. 12,13; Berglund, Lars 6,14; Havel, Peter J. 1,2
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Institution: | (1)Department of Molecular Biosciences, School of Veterinary Medicine, and (2)Department of Nutrition, UCD, Davis, California, USA. (3)College of Osteopathic Medicine, Touro University, Vallejo, California, USA. (4)UCSF, San Francisco, California, USA. (5)United States Department of Agriculture, Western Human Nutrition Research Center, Davis, California, USA. (6)Department of Internal Medicine and (7)Department of Pediatrics, School of Medicine, UCD, Sacramento, California, USA. (8)Department of Radiology, UCD Medical Center, Sacramento, California, USA. (9)Children's Hospital Oakland Research Institute, Oakland, California, USA. (10)Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, and Tufts University School of Medicine, Boston, Massachusetts, USA. (11)Diagnostic Division, Otsuka Pharmaceutical Co., Tokyo, Japan. (12)KineMed, Emeryville, California, USA. (13)Nutritional Sciences and Toxicology, University of California, Berkeley, California, USA. (14)Veterans Affairs Northern California Health Care System, Sacramento, California, USA.
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Title: | Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans.[Article]
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Source: | Journal of Clinical Investigation. 119(5):1322-1334, May 1, 2009.
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Abstract: | Studies in animals have documented that, compared with glucose, dietary fructose induces dyslipidemia and insulin resistance. To assess the relative effects of these dietary sugars during sustained consumption in humans, overweight and obese subjects consumed glucose- or fructose-sweetened beverages providing 25% of energy requirements for 10 weeks. Although both groups exhibited similar weight gain during the intervention, visceral adipose volume was significantly increased only in subjects consuming fructose. Fasting plasma triglyceride concentrations increased by approximately 10% during 10 weeks of glucose consumption but not after fructose consumption. In contrast, hepatic de novo lipogenesis (DNL) and the 23-hour postprandial triglyceride AUC were increased specifically during fructose consumption. Similarly, markers of altered lipid metabolism and lipoprotein remodeling, including fasting apoB, LDL, small dense LDL, oxidized LDL, and postprandial concentrations of remnant-like particle-triglyceride and -cholesterol significantly increased during fructose but not glucose consumption. In addition, fasting plasma glucose and insulin levels increased and insulin sensitivity decreased in subjects consuming fructose but not in those consuming glucose. These data suggest that dietary fructose specifically increases DNL, promotes dyslipidemia, decreases insulin sensitivity, and increases visceral adiposity in overweight/obese adults.
Copyright (C) 2009 The American Society for Clinical Investigation, Inc.
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Language: | English.
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Document Type: | Research Article.
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Journal Subset: | Clinical Medicine. Life Sciences.
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ISSN: | 0021-9738
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NLM Journal Code: | hs7, 7802877
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