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Each of 27 severely asthmatic 8- to 16-year-old children was evaluated at high (61.5 mg/day) and low (3.33 mg/day) steroid levels. At the high steroid level, patients reported increased depressive and anxious symptoms and performed less proficiently on a test of long-term verbal memory. No high-low steroid differences were found on measures of attention, impulsivity, hyperactivity, or motor control. The mood and memory differences were not associated with order of high and low dose, theophylline levels, or pulmonary function. Changes were generally subtle, and no evidence of steroid-induced psychiatric disturbance was documented.

Copyright 1988 (C) American Academy of Child and Adolescent Psychiatry