Information de reference pour ce titreAccession Number: | 00003688-200308000-00019.
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Author: | MARKS, P. J. 1,*; VIPOND, I. B. 2; REGAN, F. M. 3; WEDGWOOD, K. 4; FEY, R. E. 4; CAUL, E. O. 2
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Institution: | (1)Division of Epidemiology and Public Health, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH (2)Bristol Public Health Laboratory, Myrtle Road, Kingsdown, Bristol B52 8EL (3)Environmental Services Division, Derby City Council, Celtic House, Heritage Gate, Friary Street, Derby DE1 1QK (4)Southern Derbyshire Health Authority, Derment Court, Stuart St, Derby DE1 2FZ
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Title: | A school outbreak of Norwalk-like virus: evidence for airborne transmission.[Article]
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Source: | Epidemiology & Infection. 131(1):727-736, August 2003.
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Abstract: | SUMMARY: An outbreak of gastroenteritis affected a school attended by children aged 4-11 years. Epidemiological features suggested this was due to Norwalk-like virus (NLV) and this was confirmed by polymerase chain reaction (PCR). Nucleotide sequence analysis of the PCR amplicons revealed identical strains in all five positive stool samples. Pupils were significantly more likely to become ill following an episode of vomiting within their classroom (adjusted odds ratio 4.1, 95% CI 1.8-9.3). The times from exposure to illness were consistent with direct infection from aerosolized viral particles where exposure to vomiting was high. Cleaning with quaternary ammonium preparations made no impact on the course of the outbreak. However, the outbreak stopped after the school closed for 4 days and was cleaned using chlorine-based agents. This study confirms the importance of vomiting in the transmission of NLV and provides evidence that direct infection with aerosolized viral particles occurs.
(C) Cambridge University Press 2003
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Language: | English.
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Document Type: | RESEARCH ARTICLES.
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Journal Subset: | Clinical Medicine. Life Sciences.
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ISSN: | 0950-2688
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NLM Journal Code: | epi, 8703737
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Annotation(s) | |
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