Information de reference pour ce titreAccession Number: | 00002414-199805000-00016.
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Author: | CLARK, L. C. 1; DALKIN, B. 2; KRONGRAD, A. 2; COMBS, G. F. Jr 3; TURNBULL, B. W. 4; SLATE, E. H. 4; WITHERINGTON, R 5; HERLONG, J. H. 6; JANOSKO, E. 7; CARPENTER, D. 8; BOROSSO, C. 9; FALK, S. 10; ROUNDER, J. 1
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Institution: | (1)Arizona Cancer Center, College of Medicine, University of Arizona, Tucson, (2)Departments of Urology and Medicine, University of Miami School of Medicine and Geriatric Research, Education, and Clinical Center, VA Medical Center, Miami, FL, (3)Division of Nutritional Sciences, Cornell University, Ithaca, NY, (4)Statistics Center, Cornell University, Ithaca, NY, (5)Medical College of Georgia, Augusta, GA, (6)College of Medicine, University of South Carolina, Columbia, SC, (7)School of Medicine, East Carolina University, Greenville, NC, (8)Macon GA, (9)Warner Robbins GA,(10) Veterans Administration Hospital, University of Connecticut, Newington, CT, USA L.C. Clark, MPH, PhD, Associate Professor of Epidemiology. B. Dalkin, MD, Chief of Urology. A. Krongrad, MD, Chief of Urology. G.F. Combs Jr, PhD, Professor of Nutrition. B.W. Turnbull, PhD, Professor of Nutrition. E.H. Slate, PhD, Assistant Professor of Statistics. R. Witherington, MD, Urologist. J.H. Herlong, MD, Urologist. E. Janosko, MD, Urologist. D. Carpenter, MD, Urologist. C. Borosso, MD, Urologist. S. Falk, MD, Urologist. J. Rounder, MD, Urologist.
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Title: | Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial.[Article]
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Source: | British Journal of Urology. 81(5):730-734, May 1998.
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Abstract: | Objective: To test if supplemental dietary selenium is associated with changes in the incidence of prostate cancer.
Patients and method: A total of 974 men with a history of either a basal cell or squamous cell carcinoma were randomized to either a daily supplement of 200 [micro]g of selenium or a placebo. Patients were treated for a mean of 4.5 years and followed for a mean of 6.5 years.
Results: Selenium treatment was associated with a significant (63%) reduction in the secondary endpoint of prostate cancer incidence during 1983-93. There were 13 prostate cancer cases in the selenium-treated group and 35 cases in the placebo group (relative risk, RR=0.37, P=0.002). Restricting the analysis to the 843 patients with initially normal levels of prostate-specific antigen (<=4 ng/mL), only four cases were diagnosed in the selenium-treated group and 16 cases were diagnosed in the placebo group after a 2 year treatment lag, (RR=0.26 P=0.009). There were significant health benefits also for the other secondary endpoints of total cancer mortality, and the incidence of total, lung and colorectal cancer. There was no significant change in incidence for the primary endpoints of basal and squamous cell carcinoma of the skin. In light of these results, the'blinded' phase of this trial was stopped early.
Conclusions: Although selenium shows no protective effects against the primary endpoint of squamous and basal cell carcinomas of the skin, the selenium-treated group had substantial reductions in the incidence of prostate cancer, and total cancer incidence and mortality that demand further evaluation in well-controlled prevention trials.
(C) 1998 Blackwell Science Ltd.
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Author Keywords: | Prostate cancer; selenium; chemoprevention; cancer screening; diet; trace minerals; nutrition; epidemiology; clinical trials.
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References: | 1 Parker SL, Tong T, Bolden S, Wingo PA. Cancer statistics, 1996. CA Cancer J Clin 1996; 46: 5-7
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20 Clark LC, Combs GF Jr, Turnbull BW et al., For The Nutritional Prevention of Cancer Study Group. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin: a randomized clinical trial. JAMA 1996; 76: 1957-6
21 Rayman MP. Dietary selenium. Time to act. Br Med J 1997; 114: 387-8
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Language: | English.
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Document Type: | Original Papers.
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Journal Subset: | Clinical Medicine.
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ISSN: | 0007-1331
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NLM Journal Code: | b3k, 15740090r
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