Enhanced levels of the CCR7 ligands CCL19 and CCL21 in HIV infection: correlation with viral load, disease progression and response to highly active antiretroviral therapy.
Damas, Jan K a,b,d; Landro, Linn a; Fevang, Borre a; Heggelund, Lars a; Froland, Stig S a,b,c; Aukrust, Pal a,b,c
23(1):135-138, January 2, 2009.
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The CCR7 ligands, CCL19 and CCL21, coordinate lymph node homing of naive and central memory T cells. In untreated HIV-infected patients, serum levels of CCL19 and CCL21 showed a biphasic pattern during progression; a marked increase was followed by a decline in patients with advanced immunodeficiency. During highly active antiretroviral therapy, a decrease in CCL19/CCL21 levels was restricted to virologic responders. We suggest that dysregulation of CCR7 ligands may play an important role in progression of HIV infection.
(C) 2009 Lippincott Williams & Wilkins, Inc.