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: Well-characterized antibodies against [beta]-amyloid precursor protein ([beta]APP) and prion protein (PrP), and specific cRNA probes, were used to localize [beta]APP and PrP and their mRNAs in human muscle macrophages. Macrophages present in muscle biopsies of 51 patients with various neuromuscular disorders showed accumulation of [beta]APP and PrP, and strongly expressed [beta]APP and PrP mRNAs. These were present in all muscle macrophages unrelated to their localization within the muscle tissue or diagnosis. Our study provides the first demonstration that human muscle resident macrophages synthesize and accumulate [beta]APP and PrP. We suggest that those proteins play a role in biology of muscle macrophages, including their participation in inflammatory and immune responses.

(C) 1995 Wolters Kluwer Health | Lippincott Williams & Wilkins