Physical Activity and the Risk of Preeclampsia: A Systematic Review and Meta-Analysis.
Aune, Dagfinn a,b,c; Saugstad, Ola Didrik d; Henriksen, Tore e; Tonstad, Serena a,f
25(3):331-343, May 2014.
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Background: Physical activity has been hypothesized to reduce the risk of preeclampsia, but epidemiologic studies have not shown consistent results. Therefore, we conducted a systematic review and dose-response meta-analysis of epidemiologic studies.
Methods: PubMed, Embase, and Ovid databases were searched for case-control and cohort studies of physical activity and preeclampsia up to 2 November 2012. We estimated summary relative risks (RRs) using a random effects model.
Results: Fifteen studies were included. The summary RR for high versus low prepregnancy physical activity was 0.65 (95% confidence interval [CI] = 0.47-0.89, I2 = 0%; n = 5). In the dose-response analysis, the summary RR was 0.72 (0.53-0.99; I2 = 0%; n = 3) per 1 hour per day and 0.78 (0.63-0.96; I2 = 0%; n = 2) per 20 metabolic equivalent task (MET)-hours per week. The summary RR for high versus low physical activity in early pregnancy was 0.79 (0.70-0.91; I2 = 0%; n = 11). In the dose-response analysis, the summary RR per 1 hour per day was 0.83 (0.72-0.95; I2 = 21%; n = 7) and 0.85 (0.68-1.07; I2 = 69%; n = 3) per 20 MET-hours per week. A nonlinear association was observed for physical activity before pregnancy and risk of preeclampsia (test for nonlinearity, P = 0.03), but not for physical activity in early pregnancy (test for nonlinearity, P = 0.37), with a flattening of the curve at higher levels of activity. Both walking and greater intensity of physical activity were inversely associated with preeclampsia.
Conclusions: Our analysis suggests a reduced risk of preeclampsia with increasing levels of physical activity before pregnancy and during early pregnancy.
(C) 2014 by Lippincott Williams & Wilkins, Inc