Escherichia coli: Development of Carbapenem Resistance During Therapy.
Hong, Tao 1; Smith Moland, Ellen 2; Abdalhamid, Baha 2; Hanson, Nancy D. 2; Wang, Jie 1; Sloan, Cindy 1; Fabian, Diane 1; Farajallah, Awny 1; Levine, Jerome 1; Thomson, Kenneth S. 2
[Article] Clinical Infectious Diseases. 40(10):e84-e86, May 15, 2005.

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: A 76-year-old woman had recurrent urosepsis due to extended-spectrum [beta]-lactamase-positive Escherichia coli. Imipenem resistance was detected after long-term imipenem-meropenem therapy. The carbapenem-hydrolyzing enzyme gene was identified as blaKPC-3. To our knowledge, this is the first documented case in which carbapenem-resistant E. coli emerged during therapy with imipenem and meropenem, and the first identification of the carbapenem-hydrolyzing enzyme in E. coli isolates.

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