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Purpose: To determine whether an intravitreal bevacizumab injection after phacoemulsification can improve cataract surgery visual outcomes in patients with diabetic macular edema by acting on the degree of edema.

Setting: Fundacion Oftalmologica del Mediterraneo, Valencia, Spain.

Methods: We selected 26 consecutive diabetic patients with nonproliferative diabetic retinopathy and macular edema who were to undergo cataract surgery, and we divided them into two randomized groups to be studied prospectively. Group I included 13 eyes that were injected with intravitreal bevacizumab upon completion of cataract surgery; Group II included 13 control eyes that were injected with balanced salt solution.

Results: Preoperative macular thickness was 282.62 [mu]m /- 57.64 in Group I and 310.38 [mu]m /- 82.99 in Group II. Preoperative Snellen best-corrected visual acuity was 0.27 /- 0.17 and 0.24 /- 0.16 in Groups I and II, respectively. Best-corrected visual acuity at 3 and 6 months was better in Group I-0.4 /- 0.28 and 0.4 /- 0.27-whereas poorer results were observed in the control group-0.21 /- 0.13 and 0.14 /- 0.13. These mean macular thickness values differed significantly between groups at 3 months (P = 0.040) and 6 months (P = 0.004). Optical coherence tomography measured macular thickness was also better in Group I, 292.46 /- 104.75 [mu]m at 3 months and 277.62 /- 92.99 [mu]m at 6 months. For Group II, the results were 367.62 /- 75.24 [mu]m at 3 months and 387.46 /- 74.11 [mu]m at 6 months. These mean macular thickness values differed significantly between groups at 3 months (P = 0.046) and 6 months (P = 0.002).

Conclusion: Intravitreal bevacizumab immediately after phacoemulsification prevents exacerbation of the macular edema seen in many diabetic patients undergoing cataract surgery. In addition, this effect seems to hold in the short term.

(C) 2009 by Ophthalmic Communications Society, Inc.