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Summary: Background Malaria and anaemia, especially that due to iron deficiency, are two leading causes of morbidity worldwide.Little is known about the relative contribution of Plasmodium falciparum infection and iron deficiency to the aetiology of anaemia in malaria-endemic areas. We undertook a randomised comparison of different strategies for control of anaemia and malaria in infants, including an assessment of the effect of iron supplementation on malaria susceptibility.

Methods 832 infants born at one hospital in a malaria-hyperendemic area of Tanzania between January and October, 1995, were randomly assigned to group DI, receiving daily oral iron (2 mg/kg daily) plus weekly Deltaprim (3[center dot]125 mg pyrimethamine plus 25 mg dapsone); group IP, receiving iron plus weekly placebo; group DP, receiving daily placebo plus weekly Deltaprim; or group PP, receiving daily placebo plus weekly placebo. Daily supplementation was given from 8 to 24 weeks of age, and the weekly chemoprophylaxis from 8 to 48 weeks. The frequency of severe anaemia (packed-cell volume <25%) and malaria episodes was assessed through a combination of passive case detection and cross-sectional surveys.

Findings The groups that received iron supplementation had a lower frequency of severe anaemia than those that did not receive iron (0[center dot]62 vs 0[center dot]87 cases per person-year; protective efficacy 28[center dot]8% [95% CI 6[center dot]3-45[center dot]8). Iron supplementation had no effect on the frequency of malaria (0[center dot]87 vs 1[center dot]00 cases per person-year; protective efficacy 12[center dot]8% [-12[center dot]8 to 32[center dot]5]). The groups that received malaria prophylaxis had lower frequencies of both severe anaemia (0[center dot]45 vs 1[center dot]04 episodes per person-year; protective efficacy 57[center dot]3% [43[center dot]0-67[center dot]9]) and malaria (0[center dot]53 vs 1[center dot]34 episodes per person-year; protective efficacy 60[center dot]5% [48[center dot]2-69[center dot]9]) than the groups that did not receive prophylaxis. After the end of the intervention period, children who had received malaria chemoprophylaxis had higher rates of severe anaemia and malaria than non-chemoprophylaxis groups (relative risks 2[center dot]2 [1[center dot]3-3[center dot]7] and 1[center dot]8 [1[center dot]3-2[center dot]6]).

Interpretation Malaria chemoprophylaxis during the first year of life was effective in prevention of malaria and anaemia but apparently impaired the development of natural immunity.Iron supplementation was effective in preventing severe anaemia without increasing susceptibility to malaria. Our findings support iron supplementation of infants to prevent iron-deficiency anaemia, even in malaria-endemic areas.

Lancet 1997; 350: 844-50

Copyright. (C) The Lancet Ltd, 1997.