Information de reference pour ce titreAccession Number: | 00005186-200712000-00030.
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Author: | Chamlin, Sarah L. MD; Haggstrom, Anita N. MD; Drolet, Beth A. MD; Baselga, Eulalia MD; Frieden, Ilona J. MD; Garzon, Maria C. MD; Horii, Kimberly A. MD; Lucky, Anne W. MD; Metry, Denise W. MD; Newell, Brandon MD; Nopper, Amy Jo MD; Mancini, Anthony J. MD
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Institution: | Division of Pediatric Dermatology (S.C., A.M.), Children's Memorial Hospital and Departments of Pediatrics and Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, Departments of Dermatology and Pediatrics (A.H.), Indiana University, Indianapolis, IN, Department of Dermatology (B.D.), Medical College of Wisconsin, Milwaukee, WI, Department of Dermatology, Hospital de le Santa Dreu I Sant Pau (E.B.), Barcelona, Spain, Departments of Dermatology/Pediatrics (I.L.), University of California, San Francisco, CA, Departments of Dermatology and Pediatrics (M.G.), Columbia University, New York, NY, Section of Dermatology (K.H., B.N.), Children's Mercy Hospital, Kansas City, MO, Department of Dermatology (A.L.), Cincinnati Children's Hospital, Cincinnati, OH, Department of Dermatology (D.M.), Baylor College of Medicine, Houston, TX.
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Title: | |
Source: | Journal of Pediatrics. 151(6):684-689e1, December 2007.
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Abstract: | Objective: To identify clinical features of infants with ulcerated infantile hemangiomas.
Study design: Cross-sectional analysis was conducted within a prospective cohort study of children with infantile hemangiomas. Children younger than 12 years of age were recruited. Demographic and prenatal/perinatal information was collected. Hemangioma size, location, subtype, course, complications, and treatments were recorded.
Results: One thousand ninety-six patients were enrolled, and 173 (15.8%) patients experienced ulceration. Ulceration occurred in 192 (9.8%) of 1096 total hemangiomas. Hemangiomas with ulcerations were more likely large, mixed clinical type, segmental morphologic type, and located on the lower lip, neck, or anogenital region. Ulceration occurred at a median age of 4 months, most often during the proliferative phase. Children with ulcerated hemangiomas were more likely to present to a pediatric dermatologist at a younger age and to require treatment. Bleeding occurred in 41% of ulcerated lesions but was rarely of clinical significance. Infection occurred in 16%.
Conclusions: Ulceration occurs in nearly 16% of patients with infantile hemangiomas, most often by 4 months of age, during the proliferative phase. Location, size, and clinical and morphologic type are associated with an increased risk for development of ulceration.
(C) Mosby-Year Book Inc. 2007. All Rights Reserved.
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References: | 1. Haggstrom AN, Drolet BA, Baselga E, Chamlin SL, Garzon MC, Horii KA, et al. Prospective study of infantile hemangiomas: clinical characteristics predicting complications and treatment. Pediatrics 2006;118:882-887.
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Language: | English.
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Document Type: | ORIGINAL ARTICLE.
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Journal Subset: | Clinical Medicine.
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ISSN: | 0022-3476
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NLM Journal Code: | jlz, 0375410
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