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Background: There is a dearth of information regarding the occurrence of cutaneous melanoma in a large cohort of persons with large congenital melanocytic nevi (LCMN) or multiple congenital melanocytic nevi (MCMN).

Objective: The purpose of this article is to report our experience with 1008 persons having LCMN and MCMN.

Methods: Information was evaluated that was obtained from a database of persons with LCMN or MCMN voluntarily submitted by the affected persons to a nevus support group, the Nevus Network.

Results: Of those with garment LCMN, 2.9% developed cutaneous melanoma associated with 0.8% deaths. Of those with LCMN on the head or extremity, 0.3% developed cutaneous melanoma associated with no deaths to date. Of the small number with MCMN without a giant nevus, 6.7% developed cutaneous melanoma.

Limitations: Attending physician confirmation of submitted information was unavailable.

Conclusions: LCMN and MCMN were associated with a low occurrence of cutaneous melanoma in our group.

(C) 2005 by Mosby, Inc.