The Dipeptidyl Peptidase IV Inhibitor Vildagliptin Suppresses Endogenous Glucose Production and Enhances Islet Function after Single-Dose Administration in Type 2 Diabetic Patients.
Balas, Bogdan; Baig, Muhammad R.; Watson, Catherine; Dunning, Beth E.; Ligueros-Saylan, Monica; Wang, Yibin; He, Yan-Ling; Darland, Celia; Holst, Jens J.; Deacon, Carolyn F.; Cusi, Kenneth; Mari, Andrea; Foley, James E.; DeFronzo, Ralph A.
[Miscellaneous Article]
Journal of Clinical Endocrinology & Metabolism.
92(4):1249-1255, April 2007.
(Format: HTML, PDF)
Aims/Hypothesis: Vildagliptin is a selective dipeptidyl peptidase IV inhibitor that augments meal-stimulated levels of biologically active glucagon-like peptide-1. Chronic vildagliptin treatment decreases postprandial glucose levels and reduces hemoglobin A1c in type 2 diabetic patients. However, little is known about the mechanism(s) by which vildagliptin promotes reduction in plasma glucose concentration.
Methods: Sixteen patients with type 2 diabetes (age, 48 /- 3 yr; body mass index, 34.4 /- 1.7 kg/m2; hemoglobin A1c, 9.0 /- 0.3%) participated in a randomized, double-blind, placebo-controlled trial. On separate days patients received 100 mg vildagliptin or placebo at 1730 h followed 30 min later by a meal tolerance test (MTT) performed with double tracer technique (3-3H-glucose iv and 1-14C-glucose orally).
Results: After vildagliptin, suppression of endogenous glucose production (EGP) during 6-h MTT was greater than with placebo (1.02 /- 0.06 vs. 0.74 /- 0.06 mg[middle dot]kg-1[middle dot]min-1; P = 0.004), and insulin secretion rate increased by 21% (P = 0.003) despite significant reduction in mean plasma glucose (213 /- 4 vs. 230 /- 4 mg/dl; P = 0.006). Consequently, insulin secretion rate (area under the curve) divided by plasma glucose (area under the curve) increased by 29% (P = 0.01). Suppression of plasma glucagon during MTT was 5-fold greater with vildagliptin (P < 0.02). The decline in EGP was positively correlated (r = 0.55; P < 0.03) with the decrease in fasting plasma glucose (change = -14 mg/dl).
Conclusions: During MTT, vildagliptin augments insulin secretion and inhibits glucagon release, leading to enhanced suppression of EGP. During the postprandial period, a single dose of vildagliptin reduced plasma glucose levels by enhancing suppression of EGP.
Copyright (C) 2007 by The Endocrine Society