Information de reference pour ce titreAccession Number: | 00004495-200502000-00001.
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Author: | Cauley, Jane A. DrPH *; Lui, Li-Yung MA, MS +; Stone, Katie L. PhD +; Hillier, Teresa A. MD, MS ++; Zmuda, Joseph M. PhD *; Hochberg, Marc MD [S]; Beck, Thomas J. PhD [//]; Ensrud, Kristine E. MD, MPH [P]
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Institution: | (*)Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania (+)Department of Medicine, University of California at San Francisco, San Francisco, California (++)Kaiser Permanente Center for Health Research, Northwest/Hawaii, Portland, Oregon ([S])Division of Rheumatology, University of Maryland, Baltimore, Maryland ([//])Department of Radiology, The Johns Hopkins University, Baltimore, Maryland ([P])Veterans Affairs Medical Center and Department of Medicine and Epidemiology, University of Minnesota, Minneapolis, Minnesota.
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Title: | |
Source: | Journal of the American Geriatrics Society. 53(2):183-189, February 2005.
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Abstract: | OBJECTIVES: To determine whether changes in hip bone mineral density (BMD) differ in Caucasian and African American women.
DESIGN: Longitudinal study of changes in hip BMD.
SETTING: Four U.S. clinical centers.
PARTICIPANTS: Six thousand seven Caucasian (mean age 73) and 482 African-American (mean age 75) women enrolled in the Study of Osteoporotic Fractures.
MEASUREMENTS: Total hip and femoral neck BMD were measured an average of 3.5 years apart (Caucasian) and 2.0 years apart (African American). Annual absolute and percentage changes in BMD and bone mineral apparent density (BMAD) were calculated.
RESULTS: The multivariate adjusted annual percentage change in BMD was greater in Caucasian than African-American women at the total hip (-0.574%/y vs -0.334%/y) and femoral neck (-0.515%/y vs -0.203%/y) (both, P < .001). Similar findings were observed for BMAD. The average annualized rate of BMD loss was twice as high in women aged 75 and older as in women younger than 75 in both ethnic groups. The annual percentage loss in femoral neck BMD in nonusers versus hormone therapy users was (-0.57% vs -0.22%) in Caucasians and (-0.35% vs 0.64%) in African Americans (interaction P = .03).
CONCLUSION: The average rate of hip BMD loss is approximately twice as great in Caucasian as African-American women and increases with age in both groups. The hormonal and biochemical factors that contribute to ethnic differences and the increase in bone loss with advancing age need to be identified.
(C) 2005 by the American Geriatrics Society
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Author Keywords: | osteoporosis; ethnic differences; bone mineral density; bone loss; African-American women.
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References: | 1. Finkelstein JS, Lee M-LT, Sowers M et al. Ethnic variation in bone density in premenopausal and early perimenopausal women: Effects of anthropometric and lifestyle factors. J Clin Endocrinol Metab 2002;87: 3057-3067.
2. Luckey M, Meier D, Mandeli J et al. Radial and vertebral bone density in white and black women: Evidence for racial differences in premenopausal bone homeostasis. J Clin Endocrinol Metab 1989;69: 762-770.
3. Farmer M, White L, Brody J et al. Race and sex differences in hip fracture incidence. Am J Public Health 1984;74: 1374-1380.
4. Baron J, Karagas M, Barrett J et al. Basic epidemiology of fractures of the upper and lower limb among Americans over 65 years of age. Epidemiology 1996;7: 612-618.
5. Bell NH, Shary J, Stevens J et al. Demonstration that bone mass is greater in black than in white children. J Bone Miner Res 1991;6: 719-723.
6. Gilsanz V, Roe TF, Mora S et al. Changes in vertebral bone density in black girls and white girls during childhood and puberty. N Engl J Med 1991;325: 1597-1600.
7. Looker AC, Wahner HW, Dunn WL et al. Proximal femur bone mineral levels of U.S. adults. Osteoporos Int 1995;5: 389-409.
8. Cauley J, Gutai J, Kuller L et al. Black-white differences in serum sex hormones and bone mineral density. Am J Epidemiol 1994;139: 1035-1046.
9. Cummings SR. Epidemiologic studies of osteoporotic fractures: Methodologic issues. Calcif Tissue Int 1991;49((Suppl)): S15-S20.
10. Recker RR, Heaney RP. Age related bone loss in women. J Bone Miner Res 1990;5: 307-308.
11. Melton LJ, III Khosla S, Atkinson EJ et al. Cross-sectional versus longitudinal evaluation of bone loss in men and women. Osteoporos Int 2000;11: 592-599.
12. Ensrud KE, Palermo L, Black DM et al. Hip and calcaneal bone loss increase with advancing age: Longitudinal results from the study of osteoporotic fractures. J Bone Miner Res 1995;10: 1778-1787.
13. Greenspan S, Maitland LA, Myers ER et al. Femoral bone loss progresses with age: A longitudinal study in women over age 65. J Bone Miner Res 1994;9: 1959-1965.
14. Jones G, Nguyen T, Sambrook P et al. Progressive loss of bone in the femoral neck in elderly people: Longitudinal findings from the Dubbo osteoporosis epidemiology study. BMJ 1994;309: 691-695.
15. Cummings SR, Nevitt MC, Browner WS et al. Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N Engl J Med 1995;332: 767-773.
16. Steiger P, Cummings SR, Black DM et al. Age-related decrements in bone mineral density in women over 65. J Bone Miner Res 1992;7: 625-632.
17. Katzman DK, Bachrach LK, Carter DR et al. Clinical and anthropometric correlates of bone mineral acquisition in healthy adolescent girls. J Clin Endocrinol Metabolism 1991;73: 1332-1339.
18. Orwoll ES, Bauer DC, Vogt TM et al. Axial bone mass in older women. Study of Osteoporotic Fractures Research Group. Ann Intern Med 1996;124: 187-196.
19. Ensrud KE, Ewing SK, Stone KL et al. Intentional and unintentional weight loss increase bone loss and hip fracture risk in older women. J Am Geriatr Soc 2003;51: 1740-1747.
20. Melton LJ 3rd, Atkinson EJ, O'Connor MK et al. Determinants of bone loss from the femoral neck in women of different ages. J Bone Miner Res 2000;15: 24-31.
21. Cummings SR, Block G, McHenry K, Baron RB. Evaluation of two food frequency methods of measuring dietary calcium intake. Am J Epidemiol 1987;126((5)):796-802.
22. Block G, Hartman AM, Dresser CM et al. A data-based approach to diet questionnaire design and testing. Am J Epidemiol 1986;124: 453-469.
23. Parfitt A. Genetic effects on bone mass and turnover-relevance to black/white differences. J Am College Nutrition 1997;16: 325-333.
24. Luckey M, Wallenstein S, Lapinski R et al. A prospective study of bone loss in African-American and White women-a clinical research center study. J Clin Endocrinol Metab 1996;81: 2948-2956.
25. Seeman E. Editorial: Growth in bone mass and size-are racial and gender differences in bone mineral density more apparent than real? J Clin Endocrinol Metab 1998;83: 1414-1419.
26. Kleerekoper M, Nelson D, Peterson E et al. Reference data for bone mass, calciotropic hormones and biochemical markers of bone remodeling in older (77-75) postmenopausal white and black women. J Bone Miner Res 1994;9: 1267-1276.
27. Finkelstein JS, Sowers M, Greendale GA et al. Ethnic variation in bone turnover in pre- and early perimenopausal women: Effects of anthropometric and lifestyle factors. J Clin Endocrinol Metab 2002;87: 3051-3056.
28. Parfitt A, Han Z-H, Palnitkar S et al. Effects of ethnicity and age or menopause on osteoblast function, bone mineralization, and osteoid accumulation in iliac bone. J Bone Miner Res 1997;12: 1864-1873.
29. Han Z-H, Palnitkar S, Sudhaker Rao D et al. Effects of ethnicity and age or menopause on the remodeling and turnover of iliac bone: Implications for mechanisms of bone loss. J Bone Miner Res 1997;12: 498-508.
30. Beck TJ, Ruff CB, Warden KE et al. Predicting femoral strength from bone mineral data: A structural approach. Invest Radiol 1990;25: 6-18.
31. Gluer CC, Cummings SR, Pressman A et al. Prediction of hip fractures from pelvic radiographs: The study of osteoporotic fractures. The Study of Osteoporotic Fractures Research Group. J Bone Mineral Res 1994;9: 671-677.
32. Theobald TM, Cauley JA, Gluer CC et al. Black-white differences in hip geometry. The Study of Osteoporotic Fractures Research Group. Osteoporos Int 1998;8: 61-67.
33. Nelson D, Barondess D, Hendrix S et al. Cross-sectional geometry, bone strength and bone mass in the proximal femur in African-American and white postmenopausal women. J Bone Miner Res 2000;15: 1992-1997.
34. Melton L III, Atkinson EJ, O'Connor MK et al. Determinants of bone loss from the femoral neck in women of different ages. J Bone Miner Res 2000;15: 24-30.
35. Hansen M, Overgaard K, Christiansen C. Spontaneous post-menopausal bone loss in different skeletal areas-followed up by 15 years. J Bone Miner Res 1995;10: 205-210.
36. Browner WS, Seeley DG, Vogt TM et al. Non-trauma mortality in elderly women with low bone mineral density. The Study of Osteoporotic Fractures Research Group. Lancet 1991;338: 355-358.
37. Iannuzzi-Sucich M, Prestwood KM, Kenny AM. Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy older men and women. J Gerontol A Biol Sci Med Sci 2002;57A: M772-M777.
38. Ensrud KE, Cauley J, Lipschutz R et al. Weight change and fractures in older women. Study of Osteoporotic Fractures Research Group. Arch Intern Med 1997;157: 857-863.
39. Rosen CJ, Glowacki J, Craig W. Sex steroids, the insulin like growth factor regulatory system and aging. Implications for the management of older postmenopausal women. J Nutr Health Aging 1998;2: 39-44.
40. Seeman E. Pathogenesis of bone fragility in women and men. Lancet 2002;359: 1841-1850.
41. Cauley J, Robbins J, Chen Z et al. The effects of estrogen plus progestin on the risk of fracture in bone mineral density. The Women's Health Initiative. JAMA 2003;290: 1729-1738.
42. McLean RR, Hannan MT, Epstein BE et al. Elderly cohort study subjects unable to return for follow-up have lower bone mass than those who can return. Am J Epidemiol 2000;151: 689-692.
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Language: | English.
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Document Type: | Clinical Investigations.
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Journal Subset: | Clinical Medicine. Behavioral & Social Sciences.
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ISSN: | 0002-8614
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NLM Journal Code: | 7503062, h6v
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