Generation of effector CD8+ T cells and their conversion to memory T cells.
Cui, Weiguo 1; Kaech, Susan M. 1
[Review] Immunological Reviews. 236(1):151-166, July 2010.

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: Immunological memory is a cardinal feature of adaptive immunity. We are now beginning to elucidate the mechanisms that govern the formation of memory T cells and their ability to acquire longevity, survive the effector-to-memory transition, and mature into multipotent, functional memory T cells that self-renew. Here, we discuss the recent findings in this area and highlight extrinsic and intrinsic factors that regulate the cellular fate of activated CD8 T cells.

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