Information de reference pour ce titreAccession Number: | 01451459-200307010-00023.
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Author: | Jouault, Thierry 1; Ibata-Ombetta, Stella 1; Takeuchi, Osamu 3; Trinel, Pierre-Andre 1; Sacchetti, Paola 2; Lefebvre, Philippe 2; Akira, Shizuo 3; Poulain, Daniel 1
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Institution: | (1) Laboratoire de Mycologie Fondamentale et Appliquee, Inserm EMI0360, Universite de Lille II, Place Verdun, France (2) Inserm U459, Facultede Medecine H. Warembourg, Place Verdun, France (3) Department of Host Defense Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
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Title: | |
Source: | Journal of Infectious Diseases. 188(1):165-172, July 1, 2003.
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Abstract: | : Candida albicans is a common, harmless yeast in the human digestive tract that also causes severe systemic fungal infection in hospitalized patients. Its cell-wall surface displays a unique glycolipid called phospholipomannan (PLM). The ability of PLM to stimulate tumor necrosis factor (TNF)-[alpha] production by J774 mouse cells correlates with the activation of nuclear factor (NF)-[kappa]B. We examined the involvement of Toll-like receptors (TLRs) in PLM-dependent stimulation. Compared with wild-type cells, which produced large amounts of TNF-[alpha] after incubation with PLM, the deletion of the TLR4 and TLR6 genes led to a limited alteration of the PLM-induced response. Deletion of the TLR2 gene completely abolished the cell response. Surface expression of PLM is a phylogenic trait of C. albicans, and the recognition of PLM by TLRs, together with the unique pathogenic potential of C. albicans, suggests that this molecule may be a member of the pathogenassociated molecular pattern family.
(C) Copyright Oxford University Press 2003.
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Language: | English.
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Document Type: | Major Articles and Brief Reports.
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ISSN: | 0022-1899
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DOI Number: | https://dx.doi.org/10.1086/37578...- ouverture dans une nouvelle fenêtre
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