Frequency of Reduced Vancomycin Susceptibility and Heterogeneous Subpopulation in Persistent or Recurrent Methicillin-Resistant Staphylococcus aureus Bacteremia.
Khosrovaneh, Amir; Riederer, Kathleen; Saeed, Sajjad; Tabriz, Shamse M.; Shah, Amar R.; Hanna, Michel M.; Sharma, Mamta; Johnson, Leonard B.; Fakih, Mohammad G.; Khatib, Riad
[Report] Clinical Infectious Diseases. 38(9):1328-1330, May 1, 2004.

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: Vancomycin susceptibility was checked in isolates from initial and final blood samples obtained from 22 patients with persistent or recurrent methicillin-resistant Staphylococcus aureus bacteremia. The minimum inhibitory concentration of vancomycin was determined using Etest and found to have increased in 2 pairs of isolates, and results of screening in 4 [mu]g vancomycin and a modified population analysis profile suggested heteroresistance in 3 isolates (13.6%). Heteroresistance is not a common cause of persistent or recurrent bacteremia.

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