Interleukin-12 Receptor [beta]1 Deficiency Presenting as Recurrent Salmonella Infection.
Staretz-Haham, Orna 1; Melamed, Rimma 1; Lifshitz, Matitiahu 1; Porat, Nurith 2; Fieschi, Claire 3; Casanova, Jean Laurent 3,4; Levy, Jacov 1
[Report]
Clinical Infectious Diseases.
37(1):137-140, July 1, 2003.
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: We describe a child with interleukin-12 receptor [beta]1 (IL-12R[beta]1) deficiency caused by a homozygous IL12RB1 large deletion who presented at the age of 1 year with recurrent, often asymptomatic episodes of bacteremia caused by group D Salmonella species. No mycobacterial disease or other unusual infection was present. The episodes of salmonellosis were caused by an identical serovar during a period of 18 months. This is the first case of inherited IL-12R[beta]1 deficiency diagnosed after isolated, recurrent salmonellosis.
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