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EDUCATIONAL OBJECTIVES: As a result of reading this article, physicians should be able to:

1. Discuss the role of irradiation in the tissue processing of musculoskeletal allografts.

2. Explain the impact of different doses of irradiation on bactericidal contamination and biomechanical properties of allografts.

3. List the findings of published studies evaluating the clinical effectiveness of irradiated musculoskeletal allografts.

4. Describe clinical cases that may benefit from the use of properly processed bone and connective tissue allografts.

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