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Typical 2-Cys peroxiredoxins - structures, mechanisms and functions. Hall, Andrea 1; Karplus, P. A. 1; Poole, Leslie B. 2 [Review] FEBS Journal. 276(9):2469-2477, May 2009.
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: Peroxiredoxins are abundant cellular antioxidant proteins that help to control intracellular peroxide levels. These proteins may also function, in part, through an evolved sensitivity of some peroxiredoxins towards peroxide-mediated inactivation in hydrogen peroxide signaling in eukaryotes. This review summarizes recent progress in our understanding of the catalytic and regulatory mechanisms of 'typical 2-Cys' peroxiredoxins and of the biological roles played by these important enzymes in oxidative stress and nonstress-related cellular signaling. New evidence suggests localized peroxide buildup plays a role in nonstress-related signaling.
Copyright (C) 2009 Blackwell Publishing Ltd.