PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake.
Parhiz, Hamideh a,*; Shuvaev, Vladimir V. a; Pardi, Norbert b; Khoshnejad, Makan a; Kiseleva, Raisa Yu a; Brenner, Jacob S. a; Uhler, Thomas a; Tuyishime, Steven b; Mui, Barbara L. c; Tam, Ying K. c; Madden, Thomas D. c; Hope, Michael J. c; Weissman, Drew b,*; Muzykantov, Vladimir R. a,*
Journal of Controlled Release.
291:106-115, December 10, 2018.
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