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Antiviral effect of a selective COX-2 inhibitor on H5N1 infection in vitro. Lee, Suki M.Y. a; Gai, W. W. a; Cheung, Timothy K.W. a; Peiris, J. S.M. a,b,* [Miscellaneous Article] Antiviral Research. 91(3):330-334, September 2011.
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: A selective cyclooxygenase-2 (COX-2) inhibitor has been previously shown to suppress the hyper-induced pro-inflammatory responses in H5N1 infected primary human cells. Here, we demonstrate that COX-2 inhibitors suppress H5N1 virus replication in human macrophages suggesting that H5N1 virus replication (more so than seasonal H1N1 virus) is dependent on activation of COX-2 dependent signaling pathways in host cells. COX-2 and its downstream signaling pathways deserve detailed investigation as a novel therapeutic target for treatment of H5N1 disease.
(C) 2011Elsevier, Inc.