Lactoferrin and lactoferricin inhibit Herpes simplex 1 and 2 infection and exhibit synergy when combined with acyclovir.
Andersen, Jeanette Hammer *; Jenssen, Havard; Gutteberg, Tore Jarl
[Article] Antiviral Research. 58(3):209-215, May 2003.

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Lactoferrin (LF) is a multifunctional glycoprotein, which plays an important role in immune regulation and defense mechanisms against bacteria, fungi, and viruses. Upon peptic digestion of LF, a peptide called lactoferricin (Lfcin) is generated. Lfcin corresponds to the N-terminal part of the protein. In this study we investigated the antiviral activity of bovine and human Lfcin against Herpes simplex virus (HSV)-1 and HSV-2. The 50% effective concentrations (EC50) for LF and Lfcin against several clinical isolates of HSV-1 and HSV-2, including acyclovir (ACV)-resistant strains, were determined. We further evaluated the effect of the combination of either LF or Lfcin with ACV against HSV-1 and HSV-2. Synergy was observed between both LF or Lfcin in combination with ACV against the HSV laboratory strains.

The 50% effective concentration (EC50) for ACV and LF or Lfcin, when combined with ACV, could be reduced by two- to sevenfold compared to the EC50 when the drugs were used alone.

(C) 2003Elsevier, Inc.