Identification of the major human hepatic and placental enzymes responsible for the biotransformation of glyburide.
Zharikova, Olga L. a; Fokina, Valentina M. a; Nanovskaya, Tatiana N. a; Hill, Ronald A. b; Mattison, Donald R. c; Hankins, Gary D.V. a; Ahmed, Mahmoud S. a,*
[Article] Biochemical Pharmacology. 78(12):1483-1490, December 2009.

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Graphical abstract: CYP19 is the major human placental microsomal enzyme responsible for the biotransformation of glyburide. Among the metabolites formed, M5 constituted approximately 90% of the total.

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