Cellular senescence and the senescent secretory phenotype in age-related chronic diseases.
Zhu, Yi; Armstrong, Jacqueline L.; Tchkonia, Tamara; Kirkland, James L.
Current Opinion in Clinical Nutrition & Metabolic Care.
17(4):324-328, July 2014.
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Purpose of review: Possible mechanisms in cellular senescence and the senescence-associated secretory phenotype (SASP) that drive and promote chronic inflammation in multiple age-related chronic diseases are considered.
Recent findings: A series of studies about the SASP indicate that senescent cells may be involved in the development of chronic inflammatory diseases associated with aging.
Summary: Aging is a complex biological process accompanied by a state of chronic, low-grade, 'sterile' inflammation, which is a major contributor to the development of many age-related chronic disorders including atherosclerosis, osteoarthritis, Alzheimer's disease, type 2 diabetes, cancers, and others. It appears that cellular senescence plays a role in causing inflammation through the SASP. A better understanding of the contribution of senescent cells to the pathologies of chronic inflammatory disorders could have potentially profound diagnostic and therapeutic implications.
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