Origin of the Lamina Propria Dendritic Cell Network.
Bogunovic, Milena 1,2; Ginhoux, Florent 1,2; Helft, Julie 1,2; Shang, Limin 2; Hashimoto, Daigo 1,2; Greter, Melanie 1,2; Liu, Kang 3; Jakubzick, Claudia 1,2; Ingersoll, Molly A. 1,2; Leboeuf, Marylene 1,2; Stanley, Richard E. 4; Nussenzweig, Michel 3,5; Lira, Sergio A. 2; Randolph, Gwendalyn J. 1,2; Merad, Miriam 1,2,*
[Article] Immunity. 31(3):513-525, September 2009.

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: CX3CR1 and CD103 dendritic cells (DCs) in intestinal lamina propria play a key role in mucosal immunity. However, the origin and the developmental pathways that regulate their differentiation in the lamina propria remain unclear. We showed that monocytes gave rise exclusively to CD103-CX3CR1 lamina propria DCs under the control of macrophage-colony-stimulating factor receptor (M-CSFR) and Fms-like thyrosine kinase 3 (Flt3) ligands. In contrast, common DC progenitors (CDP) and pre-DCs, which give rise to lymphoid organ DCs but not to monocytes, differentiated exclusively into CD103 CX3CR1- lamina propria DCs under the control of Flt3 and granulocyte-macrophage-colony-stimulating factor receptor (GM-CSFR) ligands. CD103 CX3CR1- DCs but not CD103-CX3CR1 DCs in the lamina propria constitutively expressed CCR7 and were the first DCs to transport pathogenic Salmonella from the intestinal tract to the mesenteric lymph nodes. Altogether, these results underline the diverse origin of the lamina propria DC network and identify mucosal DCs that arise from pre-DCs as key sentinels of the gut immune system.

(C) 2009Elsevier, Inc.