Information de reference pour ce titreAccession Number: | 00042754-200706220-00003.
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Author: | Bhandoola, Avinash 1,*; von Boehmer, Harald 2,**; Petrie, Howard T. 3,***; Zuniga-Pflucker, Juan Carlos 4,****
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Institution: | (1)Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA (2)Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02115, USA (3)Scripps Florida Research Institute, Jupiter, FL 33458, USA (4)Department of Immunology, University of Toronto and Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada
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Title: | Commitment and Developmental Potential of Extrathymic and Intrathymic T Cell Precursors: Plenty to Choose from.[Review]
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Source: | Immunity. 26(6):678-689, June 2007.
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Abstract: | : T cells developing in the thymus are derived from hematopoietic stem cells (HSCs) in the bone marrow (BM). Understanding the developmental steps linking multipotent HSCs to intrathymic T lineage-committed progenitors is important for understanding cancer in T lineage cells, improving T cell reconstitution after BM transplantation, and designing gene-therapy approaches to treat defective T cell development or function. Such an understanding may also help ameliorate immunological defects in aging. This review covers the differentiation steps between HSCs and committed T cell progenitors within the thymus.
(C) 2007Elsevier, Inc.
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Language: | English.
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Document Type: | Reviews.
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Journal Subset: | Clinical Medicine. Life & Biomedical Sciences.
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ISSN: | 1074-7613
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NLM Journal Code: | 9432918, ccf
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DOI Number: | https://dx.doi.org/10.1016/j.imm...- ouverture dans une nouvelle fenêtre
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