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Pathogenic Roles of B Cells in Human Autoimmunity: Insights from the Clinic. Martin, Flavius *,1; Chan, Andrew C *,1,2 [Review] Immunity. 20(5):517-527, May 2004.
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Summary: The pathogenic roles of B cells in human autoimmune diseases involve a multitude of mechanistic pathways and include the well-established contributions of autoantibodies and immune complexes that induce local inflammatory reactions and tissue destruction. Recent results using several novel B cell-directed therapies have provided new insights into additional roles of B cells in human autoimmunity. In this review, we will highlight some of these studies and discuss how clinical insights parallel murine models of normal immunity and autoimmunity.
(C) 2004Elsevier, Inc.