The Alanine/Threonine Polymorphism of the Alpha-1-Antichymotrypsin (SERPINA3) Gene and Ruptured Intracranial Aneurysms in the Japanese Population.
Krischek, Boris a,b,c; Akagawa, Hiroyuki a,b; Tajima, Atsushi a; Narita, Akira a; Kasuya, Hidetoshi b; Hori, Tomokatsu b; Inoue, Ituro a
[Article]
Cerebrovascular Diseases.
23(1):46-49, January 2007.
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Background: Serine protease inhibitor member 3 of clade A (SERPINA3), also known as alpha-1-antichymotrypsin, inhibits the activity of cathepsin G. The release of neutrophil cathepsin G (proteolytic enzyme) can destroy the vascular matrix through degradation, platelet aggregation and coagulation disorders. In a previous report there was evidence that an alanine/threonine polymorphism was associated with the risk factor for aneurysmal subarachnoid hemorrhage (SAH) in a Polish population. We performed this study to determine whether this A15T polymorphism shows the same association in a Japanese population.
Methods: A total of 437 patients with an aneurysmal SAH and 405 control cases of Japanese origin were genotyped for the A15T polymorphism and 2 further intronic single nucleotide polymorphisms by using polymerase chain reaction and direct sequencing.
Results: In the patients with intracranial aneurysms the SERPINA3 A15T allele and genotype distribution did not differ significantly from the controls.
Conclusion: In the Japanese population the A15T polymorphism of the SERPINA3 gene is not associated with aneurysmal SAH.
(C) 2007 S. Karger AG, Basel