Information de reference pour ce titreAccession Number: | 00007529-201111110-00043.
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Author: | Wilusz, Jeremy E. 1,*; Whipple, Joseph M. 2; Phizicky, Eric M. 2; Sharp, Phillip A. 1
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Institution: | (1)Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. (2)Department of Biochemistry and Biophysics, Center for RNA Biology, University of Rochester School of Medicine, Rochester, NY 14642, USA.
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Title: | |
Source: | Science. 334(6057):817-821, November 11, 2011.
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Abstract: | : The CCA-adding enzyme [ATP(CTP):tRNA nucleotidyltransferase] adds CCA to the 3' ends of transfer RNAs (tRNAs), a critical step in tRNA biogenesis that generates the amino acid attachment site. We found that the CCA-adding enzyme plays a key role in tRNA quality control by selectively marking structurally unstable tRNAs and tRNA-like small RNAs for degradation. Instead of adding CCA to the 3' ends of these transcripts, CCA-adding enzymes from all three kingdoms of life add CCACCA. In addition, hypomodified mature tRNAs are subjected to CCACCA addition as part of a rapid tRNA decay pathway in vivo. We conjecture that CCACCA addition is a universal mechanism for controlling tRNA levels and preventing errors in translation.
Copyright (C) 2011 by the American Association for the Advancement of Science
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Language: | English.
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Document Type: | Articles.
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Journal Subset: | Life Sciences. Physical Science & Engineering.
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ISSN: | 0036-8075
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NLM Journal Code: | 0404511, uj7
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DOI Number: | https://dx.doi.org/10.1126/scien...- ouverture dans une nouvelle fenêtre
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