In vitro inhibition of SARS virus replication by human interferons.
Dahl, HELENA 1; Linde, ANNIKA 1; Strannegard, ORJAN 2
[Article] Scandinavian Journal of Infectious Diseases. 36(11-12):829-831, 2004.

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Four different types of human interferon, interferon-[beta] (IFN-[beta]), recombinant IFN-[alpha]2a and IFN-[alpha]2b and natural IFN-[alpha] were tested for antiviral activity against SARS-coronavirus. The experiments were performed using in vitro cultivated monkey Vero E6 cells. IFN-[beta] was found to be the most highly active antiviral agent, followed by natural IFN-[alpha], whereas the 2 recombinant IFN-[alpha]2 species were poorly active in the system used. These results suggest that IFN-[beta] as well as natural IFN-[alpha] may be used for the treatment of SARS.

(C) 2004 Taylor & Francis Health Sciences