THE HIGH RATE OF ADVERSE DRUG EVENTS IN CHILDREN RECEIVING PROLONGED OUTPATIENT PARENTERAL ANTIBIOTIC THERAPY FOR OSTEOMYELITIS.
Faden, Dara BA; Faden, Howard S. MD
Pediatric Infectious Disease Journal.
28(6):539-541, June 2009.
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Forty-five children treated with 82 courses of 15 different antibiotics over 344 weeks during outpatient parenteral antibiotic therapy were evaluated for adverse drug events (ADE). Fifty-one percent of the courses had an associated ADE and 32.5% of the antibiotic courses were discontinued because of ADE. Vancomycin had the highest ADE rate at 85.7% and ceftriaxone had the highest ADE-related discontinuation rate at 66.7%. Cefazolin had the lowest rate of ADE and ADE-related discontinuation rates at 0% for both.
(C) 2009 Lippincott Williams & Wilkins, Inc.