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Nuclear factor-[kappa]B (NF-[kappa]B) transcription factors and the signalling pathways that activate them are central coordinators of innate and adaptive immune responses. More recently, it has become clear that NF-[kappa]B signalling also has a critical role in cancer development and progression. NF-[kappa]B provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms. NF-[kappa]B might also regulate tumour angiogenesis and invasiveness, and the signalling pathways that mediate its activation provide attractive targets for new chemopreventive and chemotherapeutic approaches.

(C) 2006 Nature Publishing Group