The microenvironment of the tumour-host interface.
Liotta, Lance A.; Kohn, Elise C.
[Miscellaneous Article] Nature. Insight: Cancer. 411(6835):375-379, May 17, 2001.

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Throughout the entire process of cancer aetiology, progression and metastasis, the microenvironment of the local host tissue can be an active participant. Invasion occurs within a tumour-host microecology, where stroma and tumour cells exchange enzymes and cytokines that modify the local extracellular matrix, stimulate migration, and promote proliferation and survival. A new class of cancer therapies that targets this pathological communication interface between tumour cells and host cells is currently under development.

(C) 2001 Nature Publishing Group