Information de reference pour ce titreAccession Number: | 00006056-200103290-00028.
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Author: | Wilson, Rachel I.; Nicoll, Roger A.
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Institution: | Departments of Cellular and Molecular Pharmacology and Physiology, University of California, San Francisco, California 94143, USA
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Title: | Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses.[Letter]
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Source: | Nature. 410(6828):588-592, March 29, 2001.
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Abstract: | Marijuana affects brain function primarily by activating the G-protein-coupled cannabinoid receptor-1 (CB1) 1-3, which is expressed throughout the brain at high levels 4. Two endogenous lipids, anandamide and 2-arachidonylglycerol (2-AG), have been identified as CB1 ligands 5,6. Depolarized hippocampal neurons rapidly release both anandamide and 2-AG in a Ca2+-dependent manner 6-8. In the hippocampus, CB1 is expressed mainly by GABA ([gamma]-aminobutyric acid)-mediated inhibitory interneurons, where CB1 clusters on the axon terminal 9-11. A synthetic CB1 agonist depresses GABA release from hippocampal slices 10,12. These findings indicate that the function of endogenous cannabinoids released by depolarized hippocampal neurons might be to downregulate GABA release. Here we show that the transient suppression of GABA-mediated transmission that follows depolarization of hippocampal pyramidal neurons 13 is mediated by retrograde signalling through release of endogenous cannabinoids. Signalling by the endocannabinoid system thus represents a mechanism by which neurons can communicate backwards across synapses to modulate their inputs.
(C) 2001 Nature Publishing Group
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Language: | English.
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Document Type: | Letters to Nature.
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Journal Subset: | Life Sciences. Physical Science & Engineering.
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ISSN: | 0028-0836
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NLM Journal Code: | 0410462, nsc
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