Decay characteristics of HIV-1-infected compartments during combination therapy.
Perelson, Alan S.; Essunger, Paulina; Cao, Yunzhen; Vesanen, Mika; Hurley, Arlene; Saksela, Kalle; Markowitz, Martin; Ho, David D.
[Letter] Nature. 387(6629):188-191, May 8, 1997.

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Analysis of changes in viral load after initiation of treatment with potent antiretroviral agents has provided substantial insight into the dynamics of human immunodeficiency virus type 1 (HIV-1). The concentration of HIV-1 in plasma drops by [approximately] 99% in the first two weeks of treatment owing to the rapid elimination of free virus with a half-life (t1/2) of

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