Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene.
Fazeli, Amin; Dickinson, Stephanie L.; Hermiston, Michelle L.; Tighe, Robert V.; Steen, Robert G.; Small, Clayton G.; Stoeckli, Esther T.; Keino-Masu, Kazuko; Masu, Masayuki; Rayburn, Helen; Simons, Jonathan; Bronson, Roderick T.; Gordon, Jeffrey I.; Tessier-Lavigne, Marc; Weinberg, Robert A.
[Article]
Nature.
386(6627):796-804, April 24, 1997.
(Format: HTML)
The DCC (Deleted in colorectal cancer) gene was first identified as a candidate for a tumour-suppressor gene on human chromosome 18q. More recently, in vitro studies in rodents have provided evidence that DCC might function as a receptor for the axonal chemoattractant netrin-1. Inactivation of the murine Dcc gene caused defects in axonal projections that are similar to those observed in netrin-1-deficient mice but did not affect growth, differentiation, morphogenesis or tumorigenesis in mouse intestine. These observations fail to support a tumour-suppressor function for Dcc, but are consistent with the hypothesis that DCC is a component of a receptor for netrin-1.
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