A comprehensive genetic map of the human genome based on 5,264 microsatellites.
Dib, Colette; Faure, Sabine; Fizames, Cecile; Samson, Delphine; Drouot, Nathalie; Vignal, Alain; Millasseau, Philippe; Marc, Sophie; Hazan, Jamile; Seboun, Eric; Lathrop, Mark; Gyapay, Gabor; Morissette, Jean; Weissenbach, Jean
[Letter]
Nature.
380(6570):152-154, March 14, 1996.
(Format: HTML)
THE great increase in successful linkage studies in a number of higher eukaryotes during recent years has essentially resulted from major improvements in reference genetic linkage maps *RF 1-6*, which at present consist of short tandem repeat polymorphisms of simple sequences or microsatellites [7,8]. We report here the last version of the Genethon human linkage map [6]. This map consists of 5,264 short tandem (AC/TG) sub n repeat polymorphisms with a mean heterozygosity of 70%. The map spans a sex-averaged genetic distance of 3,699 cM and comprises 2,335 positions, of which 2,032 could be ordered with an odds ratio of at least 1,000:1 against alternative orders. The average interval size is 1.6 cM; 59% of the map is covered by intervals of 2 cM at most and 1% remains in intervals above 10 cM.
(C) 1996 Macmillan Magazines Ltd.