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Vertical transmission of hepatitis E virus. Khuroo, Mohammad Sultan; Kamili, Saleem; Jameel, Shahid. [Report] Lancet. 345(8956):1025-1026, April 22, 1995.
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Little is known about vertical transmission of hepatitis E virus from infected mothers to their infants.We studied eight babies born to mothers infected with hepatitis E in third trimester. One baby was icteric at birth with elevated transaminases and four babies had anicteric hepatitis. Two babies were born with hypothermia and hypoglycaemia and died within 24 h; one had massive hepatic necrosis. Hepatitis E virus RNA was detected by PCR in cord or birth blood samples of five infants. Six infants had evidence of hepatitis E infection. We conclude that hepatitis E virus is commonly transmitted from infected mothers to their babies with significant perinatal morbidity and mortality.
Copyright. (C) The Lancet Ltd, 1995.