Circulating MicroRNA Is a Biomarker of Biliary Atresia.
Zahm, Adam M.; Hand, Nicholas J.; Boateng, LaTasha A.; Friedman, Joshua R.
Journal of Pediatric Gastroenterology & Nutrition.
55(4):366-369, October 2012.
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Objective: The lack of reliable noninvasive diagnostic biomarkers of biliary atresia (BA) results in delayed diagnosis and worsened patient outcome. Circulating microRNAs (miRNAs) are a new class of noninvasive biomarkers with encouraging diagnostic utility.
Methods: We examined the ability of serum miRNAs to distinguish BA from other forms of neonatal hyperbilirubinemia. BA-specific serum miRNAs were identified using a microfluidic array platform and validated in a larger, independent sample set.
Results: The miR-200b/429 cluster was significantly increased in the sera of patients with BA relative to infants with non-BA cholestatic disorders.
Conclusions: Circulating levels of the miR-200b/429 cluster are elevated in infants with BA and have promising diagnostic clinical performance.
Copyright 2012 by ESPGHAN and NASPGHAN