Information de reference pour ce titreAccession Number: | 00003656-200404190-00001.
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Author: | Biessels, Geert Jan *,a; Bravenboer, Bert b; Gispen, Willem Hendrik c
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Institution: | (a)Department of Neurology, G03.228, Rudolf Magnus Institute of Neuroscience, University Medical Centre, P.O. Box 85500, 3508 GA Utrecht, The Netherlands (b)Department of Internal Medicine, Catharina Hospital, Eindhoven, The Netherlands (c)Department of Medical Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, The Netherlands
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Title: | |
Source: | European Journal of Pharmacology. 490(1):1-4, April 2004.
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Abstract: | : The brain has long been viewed as an insulin-insensitive organ. Following the demonstration of insulin receptors in the brain, this assumption has been challenged, and a whole new field of research has emerged. Insulin appears to play a role in brain physiology, and disturbances of cerebral insulin signalling and glucose homeostasis are implicated in brain pathology. This special issue of the European Journal of Pharmacology provides an overview of research into the involvement of glucose and insulin in the modulation of cognition and synaptic plasticity in health and in disease. In three sections, the effects of glucose and insulin on the brain will be discussed from a physiological perspective, in relation to brain ageing and Alzheimer's disease, and in relation to diabetes mellitus, respectively. These subjects will be covered from various angles, from the level of molecular neurosciences, to the level of applied neuropsychology.
(C) 2004Elsevier, Inc.
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Author Keywords: | Insulin; Brain; Learning; Cognition; Dementia; Diabetes mellitus; Insulin signalling; Glucose metabolism.
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References: | Brownlee, M., 2001. Biochemistry and molecular cell biology of diabetic complications. Nature. 414, 813-820.
Gispen, W.H., Biessels, G.J., 2000. Cognition and synaptic plasticity in diabetes mellitus. Trends Neurosci. 23, 542-549.
Havrankova, J., Roth, J., Brownstein, M., 1978. Insulin receptors are widely distributed in the central nervous system of the rat. Nature. 272, 827-829.
Le Roith, D., Zick, Y., 2001. Recent advances in our understanding of insulin action and insulin resistance. Diabetes Care. 24, 588-597.
Miles, W.R., Root, H.F., 1922. Psychologic tests applied in diabetic patients. Arch. Intern. Med. 30, 767-777.
Rosenfeld, L., 2002. Insulin: discovery and controversy. Clin. Chem. 48, 2270-2288.
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Language: | English.
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Document Type: | Editorial.
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Journal Subset: | Pharmacology.
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ISSN: | 0014-2999
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NLM Journal Code: | en6, 1254354
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DOI Number: | https://dx.doi.org/10.1016/j.ejp...- ouverture dans une nouvelle fenêtre
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