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Purpose: The purpose was to determine the interchangeability of ultrasound biomicroscopy (UBM) and anterior segment optical coherence tomography (AS-OCT) for corneal opacity depth measurement.

Methods: Twenty-six eyes of 26 consecutive patients with corneal opacities were examined by both AS-OCT and UBM. The corneal thickness and the corneal opacity depth were measured and compared. The interchangeability was determined by Bland-Altman plotting.

Results: The difference in the full corneal thickness and in the corneal opacity depth between OCT and UBM was 5 /- 7 [mu]m and -1 /- 8 [mu]m, respectively. There were strong correlations and no significant differences between the paired parameters (all r > 0.99, P < 0.01). The limits of agreement were 5 /- 14 [mu]m for the corneal thickness and -1 /- 14.8 [mu]m for the corneal opacity depth.

Conclusions: AS-OCT and UBM may be used interchangeably for measuring both full corneal thickness and corneal opacity depth in patients with corneal opacity.

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