The sensitivity of head and neck carcinoma cells to statins is related to the expression of their Ras expression status, and statin-induced apoptosis is mediated via suppression of the Ras/ERK and Ras/mTOR pathways.
Tsubaki, Masanobu; Fujiwara, Daichiro; Takeda, Tomoya; Kino, Toshiki; Tomonari, Yoshika; Itoh, Tatsuki; Imano, Motohiro; Satou, Takao; Sakaguchi, Katsuhiko; Nishida, Shozo
Clinical & Experimental Pharmacology & Physiology.
44(2):222-234, February 2017.
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