Information de reference pour ce titreAccession Number: | 00002352-200703000-00030.
|
Author: | Zucchetto, A. 1,*; Maso, L. Dal 1; Tavani, A. 2; Montella, M. 3; Ramazzotti, V. 4; Talamini, R. 1; Canzonieri, V. 5; Garbeglio, A. 6; Negri, E. 2; Franceschi, S. 7; La Vecchia, C. 2,8
|
Institution: | (1)S.O.C. Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano (PN) (2)Istituto di Ricerche Farmacologiche "Mario Negri", Milano, Italy (3)Servizio di Epidemiologia, Istituto Tumori "Fondazione Pascale", Napoli, Italy (4)Servizio Integrato di Epidemiologia e Sistemi Informativi, Istituto Nazionale Tumori "Regina Elena", Roma, Italy (5)Divisione di Anatomia Patologica, Centro di Riferimento Oncologico, Aviano (PN), Italy (6)Unita Operativa di Urologia, Azienda Ospedaliera "Santa Maria degli Angeli", Pordenone, Italy (7)International Agency for Research on Cancer, Lyon, France (8)Istituto di Statistica Medica e Biometria, Universita degli Studi di Milano, Milano, Italy
|
Title: | History of treated hypertension and diabetes mellitus and risk of renal cell cancer.[Article]
|
Source: | Annals of Oncology. 18(3):596-600, March 2007.
|
Abstract: | Background: An increased risk of renal cell cancer (RCC) has been reported in subjects with hypertension. Whether this association may vary according to sex, smoking, obesity, or RCC clinical presentation is unclear. Results on the link between diabetes mellitus and RCC are inconclusive.
Patients and methods: We conducted an Italian multicenter case-control study, including 767 (494 men, 273 women) incident cases of RCC, under 80 years of age, and 1534 hospital controls, frequency-matched to cases. Multiple logistic regression models, conditioned to center, sex, and age, and adjusted for period of interview, education, smoking, and body mass were used to estimate odds ratios (OR).
Results: Compared with subjects never treated, patients with a history of treated hypertension [OR=1.7, 95% confidence interval (CI) 1.4-2.1] reported an excess risk of RCC. This pattern was confirmed in different strata of sex, education, smoking habits, body mass, tumor histological type, stage, or grade. The attributable risk of RCC for treated hypertension in this population was 16%. A slight, nonsignificant increased risk was found for history of diabetes mellitus (OR=1.3, 95% CI 0.9-1.7).
Conclusion: A possible causal role of hypertension in renal cell carcinogenesis is supported by the consistency of the direct association.
(C) 2007 The European Society for Medical Oncology
|
Author Keywords: | case-control studies; diabetes mellitus; hypertension; renal cell cancer; risk.
|
References: | 1. Bergstrom A, Hsieh CC, Lindblad P, et al. (2001) Obesity and renal cell cancer-a quantitative review. Br J Cancer 85:984-990.
2. Tavani A and La Vecchia C. (1997) Epidemiology of renal-cell carcinoma. J Nephrol 10:93-106.
3. Weight control and physical activity. In Vainio H and Bianchini F (Eds.). In IARC Handbooks of Cancer Prevention (2002) (IARC Press, Lyon) Volume 6:.
4. Hunt JD, van der Hel OL, McMillan GP, et al. (2005) Renal cell carcinoma in relation to cigarette smoking: meta-analysis of 24 studies. Int J Cancer 114:101-108.
5. Chow WH, Gridley G, Fraumeni JF Jr, Jarvholm B. (2000) Obesity, hypertension, and the risk of kidney cancer in men. N Engl J Med 343:1305-1311.
6. Chow WH, McLaughlin JK, Mandel JS, et al. (1995) Risk of renal cell cancer in relation to diuretics, antihypertensive drugs, and hypertension. Cancer Epidemiol Biomarkers Prev 4:327-331.
7. Flaherty KT, Fuchs CS, Colditz GA, et al. (2005) A prospective study of body mass index, hypertension, and smoking and the risk of renal cell carcinoma (United States). Cancer Causes Control 16:1099-1106.
8. Heath CW Jr, Lally CA, Calle EE, et al. (1997) Hypertension, diuretics, and antihypertensive medications as possible risk factors for renal cell cancer. Am J Epidemiol 145:607-613.
9. McLaughlin JK, Chow WH, Mandel JS, et al. (1995) International renal-cell cancer study. VIII. Role of diuretics, other anti-hypertensive medications and hypertension. Int J Cancer 63:216-221.
10. Shapiro JA, Williams MA, Weiss NS, et al. (1999) Hypertension, antihypertensive medication use, and risk of renal cell carcinoma. Am J Epidemiol 149:521-530.
11. Yuan JM, Castelao JE, Gago-Dominguez M, et al. (1998) Hypertension, obesity and their medications in relation to renal cell carcinoma. Br J Cancer 77:1508-1513.
12. Fryzek JP, Poulsen AH, Johnsen SP, et al. (2005) A cohort study of antihypertensive treatments and risk of renal cell cancer. Br J Cancer 92:1302-1306.
13. Rosenberg L, Stephenson WP, Rao RS, et al. (1998) The diagnosis of renal cell cancer in relation to hypertension (United States). Cancer Causes Control 9:611-614.
14. McCredie M and Stewart JH. (1992) Risk factors for kidney cancer in New South Wales, Australia. II. Urologic disease, hypertension, obesity, and hormonal factors. Cancer Causes Control 3:323-331.
15. Grossman E, Messerli FH, Boyko V, Goldbourt U. (2002) Is there an association between hypertension and cancer mortality? Am J Med 112:479-486.
16. Lindgren AM, Nissinen AM, Tuomilehto JO, Pukkala E. (2005) Cancer pattern among hypertensive patients in North Karelia, Finland. J Hum Hypertens 19:373-379.
17. Lindblad P, Chow WH, Chan J, et al. (1999) The role of diabetes mellitus in the aetiology of renal cell cancer. Diabetologia 42:107-112.
18. Wideroff L, Gridley G, Mellemkjaer L, et al. (1997) Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark. J Natl Cancer Inst 89:1360-1365.
19. Schlehofer B, Pommer W, Mellemgaard A, et al. (1996) International renal-cell-cancer study. VI. The role of medical and family history. Int J Cancer 66:723-726.
20. Lopez-Beltran A, Scarpelli M, Montironi R, Kirkali Z. (2006) 2004 WHO classification of the renal tumors of the adults. Eur Urol 49:798-805.
21. Fuhrman SA, Lasky LC, Limas C. (1982) Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 6:655-663.
22. Breslow NE and Day NE. (1980) Statistical Methods in Cancer Research. Volume I-The Analysis of Case-Control Studies. (IARC Press, IARC Scientific Publications No. 32 Lyon).
23. Hosmer D Jr and Lemeshow S. (2001) Applied logistic regression. (John Wiley & Sons, New York, NY).
24. Bruzzi P, Green SB, Byar DP, et al. (1985) Estimating the population attributable risk for multiple risk factors using case-control data. Am J Epidemiol 122:904-914.
25. Benichou J, Chow WH, McLaughlin JK, et al. (1998) Population attributable risk of renal cell cancer in Minnesota. Am J Epidemiol 148:424-430.
26. La Vecchia C, Negri E, Franceschi S, et al. (1994) A case-control study of diabetes mellitus and cancer risk. Br J Cancer 70:950-953.
27. Kreiger N, Marrett LD, Dodds L, et al. (1993) Risk factors for renal cell carcinoma: results of a population-based case-control study. Cancer Causes Control 4:101-110.
28. Coughlin SS, Neaton JD, Randall B, et al. (1997) Predictors of mortality from kidney cancer in 332,547 men screened for the multiple risk factor intervention trial. Cancer 79:2171-2177.
|
Language: | English.
|
Document Type: | original article: epidemiology.
|
Journal Subset: | Clinical Medicine.
|
ISSN: | 0923-7534
|
NLM Journal Code: | ayf, 9007735
|
Annotation(s) | |
|
|